期刊
DYES AND PIGMENTS
卷 114, 期 -, 页码 105-109出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2014.11.004
关键词
Fluorescent probe; 'OFF-ON'; Selective; Cysteine; Bioimaging; Senstivity
资金
- National Natural Science Foundation of China [21102086, 21472118]
- Shanxi Province Science Foundation [2012021009-4, 2013011011-1]
- Shanxi Province Foundation [2012-007]
- Taiyuan Technology star special [12024703]
- Program for the Top Young and Middle-aged Innovative Talents of Higher Learning Institutions of Shanxi [2013802]
- Talents Support Program of Shanxi Province [2014401]
- CAS Key Laboratory of Analytical Chemistry for Living Biosystems Open Foundation [ACL201304]
Up to date, the design of highly selective probes for Cys, Hcy, and GSH is still a challenge and very few examples have been reported so far. In this work, the compound, N-[4-Methylcoumarin-7-yl] maleimide was synthesized and it can specially recognize on Cys as an 'OFF ON' fluorescent probe. For specific recognition on Cys of probe depends on its maleimide group, the structural and acidic differences of biothiol itself. Furthermore, the ability of probe to detect Cys in living cells (HepG2 cells) via an enhancement of the fluorescence was proved. (C) 2014 Elsevier Ltd. All rights reserved.
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