期刊
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
卷 37, 期 7, 页码 383-394出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/photob.2018.4604
关键词
Rose Bengal; photodynamic therapy; photochemical tissue bonding; photothrombosis; sonodynamic therapy
类别
资金
- European Commission within the Horizon 2020 Framework through the MSCA-ITN-ETN European Training Networks [642458]
Objective: The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). Background data: RB is a xanthene dye that due to its interesting photo- and sono-sensitive properties is gaining attention in the scientific field. Methods: This study is a literature review using the database PubMed. Results: As a photosensitizer, RB converts the triplet oxygen molecule into reactive oxygen species after irradiation with green light (532 nm). This mechanism allows for the use of photo-activated RB in photochemical tissue bonding, photodynamic therapy, antimicrobial therapy and cancer treatment, photothrombotic animal models, and other applications, including tissue engineering and treatment of tauopathies. As a sono-sensitive compound, RB is applied for sonodynamic therapy, cancer treatment, and antimicrobial therapy. Conclusions: This review outlines the versatility and effectiveness of photo- and sono-activated RB in numerous biomedical applications.
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