期刊
ADVANCED THERAPEUTICS
卷 2, 期 7, 页码 -出版社
WILEY
DOI: 10.1002/adtp.201900010
关键词
cancer immunotherapy; epitopes; peptide delivery; supramolecular assembly; vaccines
资金
- National Natural Science Foundation of China [31670977, 31870950, 51703246]
- Key Projects of Advanced Manufacturing Technology for High Quality Veterinary Drugs [17ZXGSNC00080]
- CAMS Innovation Fund for Medical Sciences [2017-I2M-4-001, 2016-I2M-3-022]
- Tianjin Innovation Promotion Plan Key Innovation Team of Immunoreactive Biomaterials
- Peking Union Medical College Graduate Student Innovation Fund [2017-1001-14]
Peptide vaccines are used in clinical cancer immunotherapy, however, they generally suffer from suboptimal immunogenicity compared to live or inactive virus vector vaccines or subunit proteins, leading to limited T-cell immune responses on their own. Here, a synthetic, supramolecular, and self-adjuvanting CD8(+) T-cell epitope vaccine assembled by the peptide amphiphile conjugated with an epitope derived from tyrosinase-related protein 2 is described. It is found that the obtained hydrogel vaccine on its own stimulates the activation of dendritic cells and elicits comparable therapeutic antitumor efficiency, but a clearly stronger endogenous CD8(+) T-cell response, compared with the vaccine comprised of peptide, adjuvant and delivery system, which is commonly used in clinic. In addition, combining this novel epitope vaccine with anti-programmed cell death protein 1 (anti-PD-1) therapy significantly improves the therapeutic efficiency against melanoma. The supramolecular assembly approach and the self-assembling peptide should undoubtedly enable a wide range of T-cell epitope vaccines without the additional use of adjuvant and delivery system, and also provide new possibilities for therapeutic peptide delivery for cancer immunotherapy.
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