Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid

The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: similar to 60 mu M, higher: similar to 700 mu M and normal: similar to 120-380 mu M) with 'turn-on' fluorogenic behaviour. (C) 2015 Elsevier Ltd. All rights reserved.