期刊
BIOMEDICAL MATERIALS
卷 14, 期 4, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1748-605X/ab1d9c
关键词
gelatin; ultra-small paramagnetic iron oxide (USPIO); graphene oxide (GO); magnetic resonance imaging (MRI); conductive composite scaffolds
资金
- Natural Science Foundation of China [81573708, 31271019, 81871334, 81801764]
- Science and Technology Program of Guangzhou [201601010270, 2017010160489, 201704030083]
- Pearl River S&T Nova Program of Guangzhou [201710010155, 201806010072]
- Science and Technology Project of Guangdong province [2015A010101313, 2015A020212021, 2017A050506011, 2017A050501013, 2017B090911012, 2018A050506040, 2018A050506019, 2018A050506021]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_16R37]
Magnetic resonance imaging (MRI), as a diagnostic tool in tissue engineering, has received widespread attention because of its ability to consistently provide degradation and absorption of implants in vivo. For some specific human tissues and organs, such as nerves, muscles and myocardium, their regeneration requires tissue engineering scaffolds have a good electrical conductivity. Graphene oxide (GO) has been extensively studied as a conductive biomaterial having mechanical reinforcement. Based on the above, we propose an MRI conductive scaffold containing gelatin (Gel)/gelatinpolycaprolactone (Gel-PCL)/ultra-small paramagnetic iron oxide (USPIO)/graphene oxide (GO) (Gel/Gel-PCL/USPIO/GO). Their physical and chemical properties as well as biocompatibility are measured in vitro. The purpose of doping USPIO was developed for non-invasive monitoring of tissue engineered implants and tissue reconstruction. Functional modification of GO to match electro-physiological requirement. Co-culture with bone marrow mesenchymal stem cells showed good biocompatibility. Blood experiments have also demonstrated the feasibility of scaffolds as tissue engineered implants. The USPIO-labeled conductive scaffold, as an effective image-guided and electrically stimulating implant, appears to be a reconstruction platform for specific tissues and organs.
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