期刊
CHEMPHOTOCHEM
卷 3, 期 6, 页码 318-326出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cptc.201800253
关键词
chemical biology; kinase inhibition; photocaging; photopharmacology; photoswitching
资金
- European Union's Horizon 2020 research and innovation programme [745626]
- Swedish Research Council [2016-03601]
- Marie Curie Actions (MSCA) [745626] Funding Source: Marie Curie Actions (MSCA)
- Swedish Research Council [2016-03601] Funding Source: Swedish Research Council
The underlying role that many kinases play in complex cellular pathways as well as disease remains unclear. To better understand the role that kinases play in both health and disease states, the use of light as an external stimulus to modulate kinase activity with high spatiotemporal resolution has gained increasing interest over the years. Herein we highlight the progress made towards the development of light-responsive kinase enzymes and small molecule inhibitors. In these examples, photolabile caging groups and photoswitchable entities have been utilised to modulate either kinase activation or inhibition in a light-controlled manner.
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