期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 24, 页码 5925-5928出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob01159e
关键词
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资金
- Xiamen Southern Oceanographic Center Project [17GYY026NF05]
- COMRA program [DY135-B2-08]
- National Natural Science Foundation of China [41676130]
A novel ergostane, sarocladione (1), was isolated from the deep-sea-derived fungus Sarocladium kiliense, along with 20 known compounds. The structure of 1 was determined mainly by a detailed analysis of its experimental and calculated NMR spectroscopic data. It is worth noting that 1 was the first steroid bearing a 5,10:8,9-diseco moiety. All 21 compounds were tested for in vitro antitumor activities against five cancer cell lines. beta-Sitostenone (7) and 4,6-dihydroxyeudesmane (20) showed significant effects on HeLa-S3 cells with the IC50 values of 9.2 mu M and 9.3 mu M, respectively.
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