期刊
CHEMICAL SCIENCE
卷 10, 期 24, 页码 6210-6214出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc02067e
关键词
-
资金
- European Research Council (ERC) [692640]
Pinacol boronic esters are highly valuable building blocks in organic synthesis. In contrast to the many protocols available on the functionalizing deboronation of alkyl boronic esters, protodeboronation is not well developed. Herein we report catalytic protodeboronation of 1 degrees, 2 degrees and 3 degrees alkyl boronic esters utilizing a radical approach. Paired with a Matteson-CH2-homologation, our protocol allows for formal anti-Markovnikov alkene hydromethylation, a valuable but unknown transformation. The hydromethylation sequence was applied to methoxy protected (-)-Delta 8-THC and cholesterol. The protodeboronation was further used in the formal total synthesis of delta-(R)-coniceine and indolizidine 209B.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据