Thermal study of pazopanib hydrochloride

The currently marketed formulation of pazopanib hydrochloride has a poor bioavailability and pharmacokinetic profile. An alternative formulation of the drug might have an improved performance. Knowledge about the thermal behavior of the drug may be instrumental in the development process of such a formulation. The aim of this study was to thermally characterize raw bulk drug material of the multiple kinase inhibitor pazopanib hydrochloride using different analytical techniques. Solid-state characterization was carried out with Fourier transform infrared spectroscopy and X-ray diffraction. Thermal characterization was performed with thermogravimetric analysis and differential scanning calorimetry. Thermal and thermodynamic parameters were assessed using the Ozawa-Flynn-Wall, Friedman and Kissinger-Akahira-Sunose isoconversional methods.