期刊
MEDCHEMCOMM
卷 10, 期 6, 页码 901-906出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9md00124g
关键词
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资金
- Australian Postgraduate Award (APA) PhD scholarship
- IMB Research Advancement Award
- Campus France the Programme Hubert Curien FASIC 2018 [41621QL]
- UQ International Scholarship (UQI)
- IMB Postgraduate Award (IMBPA)
- NHMRC [APP1059354, APP1113719]
- Wellcome Trust [WT1104797/Z/14/Z]
- ACRF
Fluorescent probes derived from the fluoroquinolone antibiotic ciprofloxacin were synthesised using a Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) to link a ciprofloxacin azide derivative with alkyne-substituted green and blue fluorophores. The azide (2) and fluorophore (3 and 4) derivatives retained antimicrobial activity against Gram-positive and Gram-negative bacteria. The use of confocal fluorescent microscopy showed intracellular penetration, which was substantially enhanced in the presence of carbonyl cyanide 3-chlorophenylhydrazone as an efflux pump inhibitor in Escherichia coli.
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