DSC study and thermodynamic modelling of the system paracetamol-o-acetylsalicylic acid

The study reports a DSC investigation of solid-liquid equilibria in the paracetamol-o-acetylsalicylic acid binary system revealing a simple eutectic behaviour. The eutectic temperature and temperatures of liquidus were determined. Further, assessed eutectic and liquidus temperatures together with the data for pure components were used for the evaluation of Redlich-Kister equation parameters for the excess Gibbs energy of binary melts. Finally, binary T-x phase diagram of the above mentioned system was calculated using the FactSage software.