期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 52, 页码 7434-7437出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc02864a
关键词
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资金
- NSERC of Canada
- FRQNT of Quebec
- PROTEO
- Sentinelle Nord
- Universite Laval
- FRQNT
- NSERC
- Canadian Institutes for Health Research Operating grant [MOP 130359]
Mortiamides A-D (1-4) are head-to-tail cyclic heptapeptides that were identified from a novel Mortierella sp. isolate obtained from marine sediments from Northern Canada. Herein we report the first total synthesis of mortiamides A-D (1-4) on a solid support by concomitant cyclization/cleavage without any oligomerization side reactions, and overall yields up to 48%. We also report on the antiplasmodial activity of mortiamides A-D (1-4). We show that three out of the four tested mortiamides (A, B and D) have moderate antiplasmodial activity, while mortiamide D (4) exhibits low micromolar activity.
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