期刊
LAB ON A CHIP
卷 19, 期 13, 页码 2265-2274出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9lc00206e
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资金
- National Science Foundation [1240443]
This work presents a low-cost, passive, flexible, polymeric pump for topical drug delivery which uses wound pH as a trigger for localized drug release. Its operation relies on a pH-responsive hydrogel actuator which swells when exposed to the alkaline pH of an infected wound. The pump enables slow release (<0.1 mu L min(-1)) of aqueous anti-bacterial solution for up to 4 hours and sustains against up to 8 kPa of backpressure. Featuring a scalable layer-by-layer fabrication technique to expand the pump into a 2 x 2 array, the device can dispense 50 mu l onto a 160 mm(2) dermal coverage within 4 hours. Robustness tests show that when integrated within a medical adhesive, the device can be worn around the forearm and can withstand various daily activities (non-intensive) for up to 12 hours. In vitro experiments demonstrate a 58 times decrease of live P. aeruginosa after 24 hours of the pump assisted antibiotics treatment.
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