期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 14, 期 134, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsif.2017.0391
关键词
complexity; agents; evolution
资金
- NIH [U54CA189201, R01GM098316, U54HL127624]
- NATIONAL CANCER INSTITUTE [U54CA189201] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U54HL127624] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM098316] Funding Source: NIH RePORTER
Complex systems theory is concerned with identifying and characterizing common design elements that are observed across diverse natural, technological and social complex systems. Systems biology, a more holistic approach to study molecules and cells in biology, has advanced rapidly in the past two decades. However, not much appreciation has been granted to the realization that the human cell is an exemplary complex system. Here, I outline general design principles identified in many complex systems, and then describe the human cell as a prototypical complex system. Considering concepts of complex systems theory in systems biology can illuminate our overall understanding of normal cell physiology and the alterations that lead to human disease.
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