Date seeds (Phoenix dactylifera L.) consumption as anti-inflammatory and immunostimulant: a systematic review

The low immunity will make the body to be susceptible to various diseases. Trauma, genetic disorders, and microorganisms can reduce immunity status. Until now, drugs have not been effective in improving body immunity, and even tend to reduce immunity Date seeds contain many polyphenol compounds that can affect the immune system, but the mechanism is unclear. This systematic review aims to explore the potential of date seeds as anti-inflammatory and immunostimulants. Articles obtained from electronic databases such as PubMed, Science Direct and Google Scholar that are published from 2014 to 2018. Keywords are used: dates seed, date seeds and immunity. The result from 5 selected articles showed that date seeds as immunostimulant can increase production of IFN-gamma, IL-2, and antioxidant status. Date seeds can also suppress pro-inflammatory mediators (TNF-alpha, IL-1, IL-1(3, IL-2, IL-6), reduce of CRP, inhibit of edema formation, inhibit of NF-kB translocation and suppress of COX2, MMP-9 expression, and IFN-gamma. It can be concluded that consumption of date seeds can potentially increase the body's immune status and have a function as anti-inflammatory.