期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 380, 期 -, 页码 250-255出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2017.07.048
关键词
Glioblastoma; High-grade glioma; Elderly; Surgical resection; Chemotherapy; Radiation therapy; Geriatric
资金
- NINDS NIH HHS [F32 NS073366, R00 NS082381, R01 NS097851, K99 NS082381] Funding Source: Medline
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults over 55 years of age. The median age of diagnosis for patients with GBM is 64 years old, with the incidence of patients between 75 and 85 increasing. The optimal treatment paradigm for elderly GBM patients continues to evolve due to the higher frequency of age-related and/or medical co-morbidities. Geriatric GBM patients have historically been excluded from larger, controlled clinical trials due to their presumed decreased likelihood of a sustained treatment response and/or a prolonged good outcome. Here, we highlight current treatment considerations of elderly GBM patients with respect to surgical, radiotherapeutic and systemic modalities, with considerations for improving future clinical outcomes for this patient population. (C) 2017 Elsevier B.V. All rights reserved.
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