期刊
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
卷 15, 期 5.5, 页码 676-678出版社
HARBORSIDE PRESS
DOI: 10.6004/jnccn.2017.0070
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资金
- Amgen Inc.,
- Genentech, Inc.,
- Genomic Health, Inc.,
- Pfizer Inc.,
- Tesaro, Inc.,
All patients with early breast cancer should be classified by subgroup through testing estrogen receptor, progesterone receptor, and HER2 status, with or without Ki-67 proliferation percentage. Genomic expression profiling aids clinical decision-making in most patients, because most are estrogen receptor-positive. The commercially available classifiers are prognostic for distant recurrence in node-negative and also node-positive patients. Patients at genomically low risk have excellent 5-year outcomes with endocrine therapy alone. Some assays also predict for benefit from adjuvant endocrine therapy and chemotherapy in node-negative and node-positive patients, but with varying levels of evidence. Genomic classifiers are also prognostic of late relapse and may predict benefit from extended adjuvant endocrine therapy.
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