期刊
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
卷 98, 期 -, 页码 309-329出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmps.2016.09.013
关键词
Biomechanics; Viscoelasticity of cells; Relaxation; Indentation
资金
- NSF [CMMI-135156, DMS-1410273, NSFC-1152800009, AFOSR-FA9550-16-1-0181]
Measuring mechanical properties of cells or cell aggregates has proven to be an involved process due to their geometrical and structural complexity. Past measurements are based on material models that completely neglect the elasticity of either the surface membrane or the interior bulk. In this work, we consider general material models to account for both surface and bulk viscoelasticity. The boundary value problems are formulated for deformations and relaxations of a closed viscoelastic surface coupled with viscoelastic media inside and outside of the surface. The linearized surface elasticity models are derived for the constant surface tension model, and the Helfrich-Canham bending model for coupling with the bulk viscoelasticity. For quasi spherical surfaces, explicit solutions are obtained for the deformation, stress-strain and relaxation behaviors under a variety of loading conditions. These solutions can be applied to extract the intrinsic surface and bulk viscoelastic properties of biological cells or cell aggregates in the indentation, electro-deformation and relaxation experiments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据