期刊
FRONTIERS IN SYSTEMS NEUROSCIENCE
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnsys.2019.00028
关键词
habits; goal-directed behavior; striatum; prefrontal cortex; dorsomedial striatum; dorsolateral striatum
资金
- H2020 European Research Council [ERC-CoG-770951]
- Israel Science Foundation [393/12, 1796/12, 1062/18]
- European Union FP7 People: Marie Curie Fellowship [PCIG13-GA-2013-618201]
- Israeli Ministry of Public Security
- National Institute for Psychobiology in Israel, Hebrew University of Jerusalem
- Edmond and Lily Safra Center for Brain Sciences
- Zuckerman
- Canadian Institute for Advanced Research
Here, we review the neural circuit bases of habits, compulsions, and addictions, behaviors which are all characterized by relatively automatic action performance. We discuss relevant studies, primarily from the rodent literature, and describe how major headway has been made in identifying the brain regions and neural cell types whose activity is modulated during the acquisition and performance of these automated behaviors. The dorsal striatum and cortical inputs to this structure have emerged as key players in the wider basal ganglia circuitry encoding behavioral automaticity, and changes in the activity of different neuronal cell-types in these brain regions have been shown to co-occur with the formation of automatic behaviors. We highlight how disordered functioning of these neural circuits can result in neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD) and drug addiction. Finally, we discuss how the next phase of research in the field may benefit from integration of approaches for access to cells based on their genetic makeup, activity, connectivity and precise anatomical location.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据