期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 56, 页码 8170-8173出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc04517a
关键词
-
资金
- National Key Research and Development Program of China [2017YFA0208100, 2016YFA0200104]
- National Science Foundation of China [21778056, 21790390, 21790391, 21621062, 21435007]
Lipid-complexed small interfering RNA (siRNA) nanoparticles are promising gene regulation materials with excellent genetic, but little cellular, selectivity. Herein, we report a chemical strategy to enhance the gene silencing selectivity of these nanoparticles against cancer cells through the covalent integration of a reactive oxygen species (ROS)-degradable thioketal into the lipid nanoparticles. These lipid nanoparticles can efficiently deliver siRNA into cells, and selectively silence cancer cell gene expression in response to the high levels of intracellular ROS in cancer cells.
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