期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 57, 页码 8231-8234出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc03653a
关键词
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资金
- Open Project of State Key Laboratory of Natural Medicines [SKLNMZZCX 201815]
- National Natural Science Foundation of China [81872983, 2018ZX09711-001-007]
Withangulatin A (WA) has been reported to exhibit potent antitumor activity. However, its possible mechanism and direct proteomic targets remain unknown. Herein we report the subcellular localization of WA by designing and synthesizing its fluorescent analogues with coumarin moieties. Furthermore, sarco/endoplasmic reticulum calcium-ATPase (SERCA)2 was identified as the potential target of WA for its antitumor activity by chemical proteomics.
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