期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 72, 期 -, 页码 163-170出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2017.05.003
关键词
Antibiotics; Biomechanical properties; PMMA bone cement; Sustained release; Compression strength; Bending modulus
资金
- Biomedical Engineering Programme (BEP) [ICES/14-422A02]
- Institute of Chemical Engineering and Sciences
- Agency of Science Technology and Research (A*STAR), Singapore
The influence of mesoporous silica nanoparticles (MSNs) loaded with antibiotics on the mechanical properties of functional poly(methyl methacrylate)-(PMMA) based bone cements is investigated. The incorporation of MSNs to the bone cements (8.15 wt%) shows no detrimental effects on the biomechanical properties of the freshly solidified bone cements. Importantly, there are no significant changes in the compression strength and bending modulus up to 6 months of aging in PBS buffer solution. The preserved mechanical properties of MSN-functionalized bone cements is attributed to the unchanged microstructures of the cements, as more than 96% of MSNs remains in the bone cement matrix to support the cement structures after 6 months of aging. In addition, the MSN-functionalized bone cements are able to increase the drug release of gentamicin (GTMC) significantly as compared with commercially available antibiotic -loaded bone cements. It can be attributed to the loaded nano sized MSNs with uniform pore channels which build up an effective nano-network path enable the diffusion and extended release of GTMC. The combination of excellent mechanical properties and sustainable drug delivery efficiency demonstrates the potential applicability of MSN-functionalized PMMA bone cements for orthopedic surgery to prevent post-surgery infection.
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