期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 68, 期 -, 页码 276-286出版社
ELSEVIER
DOI: 10.1016/j.jmbbm.2017.02.004
关键词
Chemically synthesized magnetite nanoparticles (CMNPs); Biosynthesized magnetite nanoparticles (BMNPs); Luteinizing hormone-releasing hormone (LHRH); Breast specific antibody (BSA); Ephrin type-A receptor 2 (EphA2)
资金
- World Bank STEP B Program
- World Bank African Centers of Excellence Program (PAMI) [P126974]
- African Capacity Building Foundation (ACBF) [292]
- Nelson Mandela Institution (NMI)
- African University of Science and Technology (AUST)
- African Development Bank (AfDB)
- Princeton University Old Schools Innovation Fund [25105-B0635-FA572]
This paper presents the results of an experimental study of the adhesion forces between components of model conjugated magnetite nanoparticle systems for improved selectivity in the specific targeting of triple negative breast cancer. Adhesion forces between chemically synthesized magnetite nanoparticles (CMNPs), biosynthesized magnetite nanoparticles (BMNPs), as well as their conjugated systems and triple negative breast cancer cells (MDA-MB-231) or normal breast cells (MCF 10A) are elucidated at a nanoscale. In all cases, the BMNPs had higher adhesion forces (to breast cancer cells and normal breast cells) than CMNPs. The adhesion of LHRH-conjugated BMNPs or BSA-conjugated BMNPs to cancer cells is shown to be about 6 times to that of normal breast cells. The increase in adhesion forces between luteinizing hormone-releasing hormone, LHRH- or EphA2, a breast specific antibody(BSA)-conjugated BMNPs to breast cancer cells is attributed to van der Waals interactions between the peptides/antibodies from the conjugated nanoparticles and the over-expressed receptors (revealed using immunofluorescence staining) on the surfaces of the breast cancer. The implications of the results are discussed for the selectivity and specificity of breast cancer targeting by ligand-conjugated BMNPs.
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