期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 65, 期 -, 页码 66-76出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2016.07.034
关键词
Electrospinning; Solution property; Composite nanofiber scaffolds; Mechanical property; Antimicrobial effect; Tissue engineering
资金
- Basic Science Research Program through National Research Foundation of Korea (NRF) by Ministry of Education, Science and Technology [NRF-2015R1C1A1A02036404]
- Human Resource Training Program for Regional Innovation and Creativity through National Research Foundation of Korea by Ministry of Education [NRF-2015H1C1A1035635]
Silver nanoparticles embedded within a nanofibrous polymer matrix have significant attention in recent years as an antimicrobial wound dressing materials. Herein, we have fabricated a novel Ag-polyurethane-zein hybrid nanofibrous scaffold for wound dressing applications. AgNPs were synthesized in-situ via reduction of silver nitrate in electrospinning solution. Varying mass composition of the components showed the pronounced effect on the morphology and physicochemical properties of the composite fibers. Field Emission Scanning, Electron Microscopy (FESEM) images revealed that PU and zein with mass ratio 2:1 produced the bead-free continuous and uniformly distributed nanofibers. Fourier-transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD) and Thermogravimetric Analysis (TGA) confirmed the well interaction between component polymers. Compared to the pristine PU nanofibers, composite fibers showed enhanced tensile strength, young's modulus and surface wettability. The antibacterial capacity of the nanofibrous membrane was evaluated against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia cold) bacterial strains via a zone of inhibition test, and the results showed high antibacterial performance for Ag incorporated composite mat. Experimental results of cell viability assay and microscopic imaging revealed that as-fabricated scaffolds have an excellent ability for fibroblast cell adhesion, proliferation and growth. Overall, as fabricated antibacterial natural/synthetic composite scaffold can be a promising substrate for repairing skin defects. (C) 2016 Published by Elsevier Ltd.
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