期刊
GREEN CHEMISTRY
卷 21, 期 13, 页码 3547-3551出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9gc00570f
关键词
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资金
- National Natural Science Foundation of China [21861015, 21861006]
- Guangxi Natural Science Foundation of China [2017GXNSFBA198205, 2018GXNSFBA138050, 2018GXNSFAA138165]
- Key R & D Project for Science Research and Technology Development of Guilin [20170108-10]
- Guangxi Funds for Distinguished Experts
- Youth Promotion Fund of Guangxi [2017KY0475, 2018KY0400]
- Guangxi Science and Technology Base and Talents Program [AD18281035, AD18281028]
A simple and efficient Se-radical triggered cyclization/substitution cascade reaction of alkyne-tethered cyclohexadienones to afford 5-hydroxy-3-selenyl-4a,8a-dihydro-2H-chromen-6(5H)-ones has been developed. This transformation via the 3,5-diselenyl-4a,8a-dihydro-2H-chromen-6(5H)-one intermediate followed by hydrolysis in the presence of CsOAc affords the desired product 3. The resulting products were tested for their in vitro anticancer activity using MTT assay, and compounds 3e and 3q showed potent cancer cell-growth inhibition activities.
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