期刊
IN VIVO
卷 33, 期 4, 页码 1165-1174出版社
INT INST ANTICANCER RESEARCH
DOI: 10.21873/invivo.11587
关键词
Periodontitis; oral cavity; metabolomics; NMR
资金
- National Science Centre, Poland [UMO-2018/29/B/NZ2/01930]
- Wroclaw University of Technology [S40531/Z0303]
- Natural Science Centre, Poland [UMO-2018/30/A/NZ5/00650]
Chronic periodontitis is an inflammatory disease of tooth-supporting tissues associated with Porphyromonas gingivalis. Expansion and invasion of this bacterium into the periodontium is associated with changes in the metabolome of the oral cavity. Materials and Methods: Metabolomics analysis of mouth washout and tongue swab samples based on proton nuclear magnetic resonance (H-1-NMR) method was employed to determine metabolic status of the oral cavity in chronic periodontal disease. Results: Mouth washout extracts contained a total of 23 metabolites and tongue swab extracts contained 17. Identified metabolites partially overlap with the content of saliva and gingival crevicular fluid. The colonization of the oral cavity of patients with periodontitis by bacteria was manifested in the change in levels of eight metabolites. Conclusion: NMR-based metabolomics analysis is a potentially useful methodological approach for monitoring the pathological processes observed in the oral cavity in the course of periodontitis.
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