期刊
CHEMICAL SCIENCE
卷 10, 期 21, 页码 5484-5488出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc00833k
关键词
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资金
- MICIU [CTQ2016-75520-P]
- European Research Council [ERC-2015-CoG 681840 - CATA-LUX]
- AGAUR [2017 SGR 981]
- MEFP [FPU14/06541]
We report a photoinduced three-component radical process, which couples readily available alkyl chlorides, maleimides, and heteroaromatic fragments to rapidly generate complex chiral products with high diastereocontrol. This method generates radicals via an S(N)2-based photochemical catalytic mechanism, which is not reliant on the redox properties of the precursors. It therefore grants access to open-shell intermediates from substrates that would be incompatible with or inert to classical radical-generating strategies. The redox-neutral conditions of this process make it tolerant of redox-sensitive substrates and allow the installation of multiple biologically relevant heterocycles within the cascade products.
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