期刊
BIOMATERIALS SCIENCE
卷 7, 期 6, 页码 2272-2276出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9bm00395a
关键词
-
资金
- AIRC Project [IG-19859]
- Swedish Research Council [621-2011-5189]
We report herein on a novel water-soluble beta-cyclodextrin-branched polymer covalently integrating a fluorescein moiety and a nitric oxide (NO) photodonor within its macromolecular skeleton. Photoexcitation with visible light induces the parallel activation of the two chromophores, which results in the green fluorescence emission suitable for imaging accompanied by NO release for therapy. In fact, this polymer internalizes in squamous carcinoma cancer cells in vitro, visualized by fluorescence microscopy, and induces cell mortality as result of the NO photo-decaging. The non-covalent drug delivery capability of this new material is also demonstrated using a hydrophobic photosensitizer for photodynamic therapy as a probe.
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