期刊
BIOMEDICINES
卷 7, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines7020037
关键词
angiogenesis; pro-angiogenesis; anti-angiogenesis; anticancer; growth factors; integrin alpha v beta 3; vascular endothelial growth factor (VEGF); vascularization; endothelial cells
Angiogenesis assays allow for the evaluation of pro- or anti-angiogenic activity of endogenous or exogenous factors (stimulus or inhibitors) through investigation of their pro-or anti- proliferative, migratory, and tube formation effects on endothelial cells. To model the process of angiogenesis and the effects of biomolecules on that process, both in vitro and in vivo methods are currently used. In general, in vitro methods monitor specific stages in the angiogenesis process and are used for early evaluations, while in vivo methods more accurately simulate the living microenvironment to provide more pertinent information. We review here the current state of angiogenesis assays as well as their mechanisms, advantages, and limitations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据