期刊
DRUG DELIVERY
卷 23, 期 7, 页码 2497-2512出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717544.2015.1019653
关键词
Archaeobacteria; archaeosomes; cell delivery; drug delivery; gene delivery
资金
- Department of Biotechnology (DBT), New Delhi (under IYBA scheme) [BT/01/IYBA/2009]
Archaeosomes as liposomes made with one or more ether lipids that are unique to the domain of Archaeobacteria, found in Archaea constitute a novel family of liposome. Achaean-type lipids consist of archaeol (diether) and/or caldarchaeol (tetraether) core structures. Archaeosomes can be produced using standard procedures (hydrated film submitted to sonication, extrusion and detergent dialysis) at any temperature in the physiological range or lower, therefore making it possible to encapsulate thermally stable compounds. Various physiological as well as environmental factors affect its stability. Archaeosomes are widely used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery and delivery of natural antioxidant compounds. In this review article, our major aim was to explore the applications of this new carrier system in pharmaceutical field.
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