期刊
HETEROCYCLES
卷 99, 期 1, 页码 310-323出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-18-S(F)26
关键词
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资金
- KAKENHI [16H01127, 16H00999, 26253001, 18H02549, 18H04231, 18H04379, 18K18462]
- Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED [JP18am0101100]
- Grants-in-Aid for Scientific Research [16H00999, 18K18462, 16H01127, 18H04231, 18H04379] Funding Source: KAKEN
Synthetic studies on plakinidines are described. As a model study for the construction of the dihydropyridone ring at the final stage of the synthesis, we investigated a Meyer-Schuster rearrangement/aza-Michael cyclization cascade. The B,C,D,E ring system possessing a pyrrolo[2,3,4-kl]acridine structure was constructed via a benzyne-mediated cyclization/functionalization sequence that involved the formation of a beta,beta-diarylethylamine derivative and a palladium-catalyzed double aryl amination of a 3-arylindoline intermediate as key processes.
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