期刊
THERANOSTICS
卷 9, 期 17, 页码 4971-4981出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.35560
关键词
Au hollow nanorods; chimeric peptide; NIR-II photothermal therapy; real-time apoptosis imaging; reduced skin damage
资金
- National Natural Science Foundation of China [21778020, 31750110464]
- National Key R&D Program of China [2016YFD0500706]
- Fundamental Research Funds for the Central Universities [2662015QD026]
- Sci-tech Innovation Foundation of Huazhong Agriculture University [2662017PY042, 2662018PY024]
- Talented Young Scientist Program of Huazhong Agricultural University [42000481-7]
The strategy that combines photodynamic therapy (PDT) and photothermal therapy (PTT) is widely used to achieve strong antitumor efficiency. Since light in the NIR-II window possesses ideal penetration ability, developing NIR-II PTT and NIR-II light triggered photosensitizer release for combined PDT and PTT is very promising in nanomedicine. Methods: We develop a novel nanocarrier (termed AuHNRs-DTPP) by conjugating photosensitizer contained chimeric peptide (DTPP) to Au hollow nanorods (AuHNRs). AuHNRs was obtained by a Te-templated method with the assistance of L-cysteine. The chimeric peptide PpIX-PEG8-GGK(TPP) GRDEVDGC (DTPP) was obtained through a solid-phase peptide synthesis (SPPS) method. Results: Under the 1064 nm laser irradiation, the nanocarrier can accumulate heat quickly for efficient PTT, and then release activated photosensitizer for real-time apoptosis imaging. Thereafter, supplementary PDT can be conducted to kill tumor cells survived from the PTT, and meanwhile the normal tissue can be protected from photo-toxicity. Conclusion: This designed AuHNRs-DTPP nanocarrier with remarkable therapy effect, real-time apoptosis imaging ability and reduced skin damage is of great potential in nanomedicine application.
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