期刊
TRENDS IN CANCER
卷 5, 期 8, 页码 506-520出版社
CELL PRESS
DOI: 10.1016/j.trecan.2019.07.001
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资金
- Dr Leopold and Carmen Ellinger Foundation
- Gert and Susanna Mayer foundation
- 'Verein zur Forderung von Wissenschaft und Forschung an der Medizinischen Fakultat der LMU Munchen' (WiFoMed)
- Mehr LEBEN fur krebskranke Kinder - Bettina-Brau-Stiftung
- Matthias-Lackas Foundation
- Friedrich-Baur foundation
- Dr Rolf M. Schwiete foundation
- Barbara and Hubertus Trettner foundation
- Wilhelm-Sander-Foundation [2016.167.1]
- Deutsche Forschungsgemeinschaft [DFG-391665916]
- German Cancer Aid [DKH-70112257]
Stromal Antigen 1 and 2 (STAG1/2) are key subunits of the cohesin complex that mediate sister chromatid cohesion, DNA repair, transcriptional regulation, and genome topology. Genetic alterations comprising any of the 11 cohesin-associated genes possibly occur in up to 26% of patients included in The Cancer Genome Atlas (TCGA) studies. STAG2 shows the highest number of putative driver truncating mutations. We provide a comprehensive review of the function of STAG1/2 in human physiology and disease and an integrative analysis of available omics data on STAG alterations in a wide array of cancers, comprising 53 691 patients and 1067 cell lines. Lastly, we discuss opportunities for therapeutic intervention.
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