期刊
JHEP REPORTS
卷 1, 期 2, 页码 120-130出版社
ELSEVIER
DOI: 10.1016/j.jhepr.2019.05.001
关键词
Hepatitis B virus; liver cancer; HCC; coinfection; molecular pathogenesis; defective; superinfection
资金
- Asociacion Espanola para el Estudio del Higado (AEEH)
- DoD Translational Team Science Award [CA150272P3, CA150272P1]
- NCI [P30-CA196521]
- European Commission (EC)/Horizon 2020 Program (HEPCAR) [667273-2]
- EIT Health (CRISH2) [18053]
- Accelerator Award (CRUCK) (HUNTER) [C9380/A26813]
- Accelerator Award (AEEC) (HUNTER) [C9380/A26813]
- Accelerator Award (AIRC) (HUNTER) [C9380/A26813]
- Samuel Waxman Cancer Research Foundation
- Spanish National Health Institute [SAF2016-76390]
- Generalitat de Catalunya/AGAUR [SGR-1358]
- CDMRP [893275, CA150272P3, 893273, CA150272P1] Funding Source: Federal RePORTER
Hepatitis delta virus (HDV) is a small defective virus that needs hepatitis B virus (HBV) to replicate and propagate. HDV infection affects 20-40 million people worldwide and pegylated interferon (PegIFN) is the only recommended therapy. There is limited data on the contribution of HDV infection to HBV-related liver disease or liver cancer. Evidence from retrospective and cohort studies suggests that HBV/HDV coinfection accelerates progression to cirrhosis and is associated with an increased risk of hepatocellular carcinoma (HCC) development compared to HBV mono-infection. Although the life cycle of HDV is relatively well known, there is only ancillary information on the molecular mechanisms that can drive specific HDV-related oncogenesis. No thorough reports on the specific landscape of mutations or molecular classes of HDV-related HCC have been published. This information could be critical to better understand the uniqueness, if any, of HDV-related HCC and help identify novel targetable mutations. Herein, we review the evidence supporting an oncogenic role of HDV, the main reported mechanisms of HDV involvement and their impact on HCC development. (c) 2019 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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