期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 27, 页码 6607-6611出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob01165j
关键词
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资金
- NSF [CHE-1665122]
- NIH [1R01GM120240-01]
- NSFC [21629201]
Synergistic palladium and enamine catalysis was explored to promote ketone addition to unactivated olefins. A secondary amine-based organocatalyst was identified as the optimal co-catalyst for the directed Pd-catalyzed alkene activation. Furthermore, asymmetric hydrocarbon functionalization of unactivated alkenes was also achieved with good to excellent yield (up to 96% yields) and stereoselectivity (up to 96% ee). This strategy presented an efficient approach to prepare alpha-branched ketone derivatives under mild conditions.
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