期刊
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
卷 11, 期 6, 页码 385-391出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jash.2017.04.006
关键词
Salt-induced hypertension; pathogenesis; risk factors
Essential hypertension is common and is associated with significant morbidity and mortality. However, questions remain as to the exact physiological mechanisms underlying this disease. First, we discuss how essential hypertension may be largely a result of a maladaptation to a high-salt diet and that high blood pressure, rather than being an inactive side effect of high salt intake, may be an adaptive mechanism to improve salt secretion. Next, we explain how any physiological state that reduces urinary sodium concentrating ability may increase an individual's risk for salt-induced hypertension. Finally, we conclude that natriuresis is a crucial criterion for effective long-term pharmacologic treatment of essential hypertension. Copyright (C) 2017 American Society of Hypertension. All rights reserved.
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