期刊
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
卷 11, 期 1, 页码 10-19出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jash.2016.10.004
关键词
Ciprofibrate; hypertension; omega-3 fatty acids; arterial stiffness; cardiovascular risk; hypertriglyceridemia
资金
- CNPq [309316/2012-0]
- FAPERJ [E-26/103.309/2011]
Association between hypertriglyceridemia and cardiovascular (CV) disease is still controversial. The purpose of this study was to compare omega-3 and ciprofibrate effects on the vascular structure and function in low and high CV risk hypertensive patients with hypertriglyceridemia. Twenty-nine adults with triglycerides 150-499 mg/dL were divided into low (<7.5%) and high (>7.5%) CV risk, randomized to receive omega-3 fatty acids 1800 mg/d or ciprofibrate 100 mg/d for 12 weeks. Treatment was switched after 8-week washout. Clinical evaluation and vascular tests were assessed at baseline and after intervention. Peripheral (131 +/- 3 to 125 +/- 3 mm Hg, P <.05) and aortic (124 +/- 3 to 118 +/- 2 mg/dL, P <.05) systolic blood pressure were decreased by ciprofibrate in low-risk patients. In high-risk patients, pulse wave velocity was reduced (10.4 +/- 0.4 to 9.4 +/- 0.3 m/s, P <.05) and flow-mediated dilation was increased (11.1 +/- 1.6 to 13.5 +/- 1.2%, P <.05) by omega-3. In conclusion, omega-3 improved arterial stiffness and endothelial function, pointing out the beneficial effect of this therapy on vascular aging, in high-risk patients. (C) American Society of Hypertension. All rights reserved.
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