期刊
META GENE
卷 21, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mgene.2019.100593
关键词
IL-6; IL6ST; C-reactive protein; rs1800795; Atherosclerosis; Inflammation
资金
- Russian Science Foundation [18-75-00087]
- Russian Science Foundation [18-75-00087] Funding Source: Russian Science Foundation
Inflammation is an important factor in the onset and development of pathological lesions of coronary arteries. Various cytokines, including interleukin-6 (IL-6), and pattern recognition receptors, such as C-reactive protein (CRP), are the key inflammatory mediators. We aimed to identify associations of single nucleotide polymorphisms (SNPs) rs1800795 of the IL-6 gene and rs3729960 of the IL6ST gene with levels of inflammatory markers and coronary lesions. The study included 316 men and 131 women (mean age 61.2 +/- 9.4 years) subjected to coronary angiography. IL-6 levels were assayed by ELISA and high sensitivity CRP (hsCRP) levels were measured by turbidimetry. The rs1800795 and rs3729960 genotypes of the IL-6 and IL6ST genes, respectively, were determined by real time PCR. Data were analyzed by the SPSS software. In women, the CC genotype (N = 31) of rs1800795 of the IL-6 gene is associated with lower concentrations of hsCRP in the dominant model (GG + CG; N = 38 and N = 62, respectively) and the corresponding hsCRP levels were significantly different (P = .015) at 1.70 mg/l (25% 0.75; 75% 3.55) and 3.30 mg/l (25% 1.20; 75% 6.18). In men, these genotypes were not associated with hsCRP levels. Distribution of allele frequency of rs1800795 of the IL-6 gene in groups with and without coronary lesions indicate that the G allele has significantly higher frequency in men but not in women with coronary atherosclerosis (OR 2.45; 95% CI 1.31-4.72; P = .003). Thus, in women, rs1800795 of the IL-6 gene is associated with hsCRP levels and in men, rs1800795 is associated with presence of coronary lesions.
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