期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 65, 期 5, 页码 E95-E100出版社
WILEY
DOI: 10.1111/jgs.14791
关键词
Alzheimer's disease; epidemiology; oral health; prospective cohort study; vascular dementia
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [16H02644, 16H02692, 26350895, 26460748, 15K09267, 15K08738, 15K09835, 16K09244, 15K20644]
- Ministry of Health, Labour and Welfare of Japan [H25-Junkankitou [Seishuu]-Sitei-022, H26-Junkankitou [Seisaku]-Ippan-001, H27-Shokuhin-[Sitei]-017]
- Japan Agency for Medical Research and Development (AMED) (CREST) [16dk0207025h0001, 16ek0210042h0002, 16gm0610007h0204]
- Grants-in-Aid for Scientific Research [15K09267, 15K09835, 16H05850, 26460748, 15K20644, 16K09244, 16H02644, 16H02692, 15K08738, 26350895] Funding Source: KAKEN
ObjectivesTo clarify the effect of tooth loss on development of all-cause dementia and its subtypes in an elderly Japanese population. DesignProspective cohort study. SettingThe Hisayama Study, Japan. ParticipantsCommunity-dwelling Japanese adults without dementia aged 60 and older (N=1,566) were followed for 5years (2007-2012). MeasurementsParticipants were classified into four categories according to baseline number of remaining teeth (20, 10-19, 1-9, 0). The risk estimates of the effect of tooth loss on the development of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were computed using a Cox proportional hazards model. ResultsDuring follow-up, 180 (11.5%) subjects developed all-cause dementia; 127 (8.1%) had AD, and 42 (2.7%) had VaD. After adjusting for potential confounders, there was a tendency for the multivariable-adjusted hazard ratio of all-cause dementia to increase with decrease in number of remaining teeth (P for trend=.04). The risk of all-cause dementia was 1.62 times as great in subjects with 10 to 19 teeth, 1.81 times as great in those with one to nine teeth, and 1.63 times as great in those with no teeth as in those with 20 teeth or more. An inverse association was observed between number of remaining teeth and risk of AD (P for trend=.08), but no such association was observed with risk of VaD (P for trend=.20). ConclusionTooth loss is associated with an increased risk of all-cause dementia and AD in the Japanese population.
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