期刊
FOOD & FUNCTION
卷 10, 期 6, 页码 3660-3670出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9fo00463g
关键词
-
资金
- U.S. National Institutes of Health [CA120915, CA072720, ES005022]
- John L. Colaizzi Chair Endowment fund
- National Natural Science Foundation of China [31171750, 31801541]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
In this study, we investigated the effects of a newly synthesized alpha-galacto-oligosaccharide mixture (alpha-GOSg), 0.5% in drinking water, on high-fat/western-style diet (HFWD)-induced metabolic abnormality in mice in a study of 13 weeks. Raffinose family oligosaccharides (RFOs) were included as a comparison. Mice treated with alpha-GOSg had significantly lower body weight and body fat (p < 0.05), while RFOs were less effective. Both alpha-GOSg and RFOs significantly reduced serum levels of total cholesterol and low-density lipoprotein cholesterol, alanine aminotransferase and liver lipids. However, only alpha-GOSg significantly decreased the histopathological score for liver steatosis and downregulated hepatic fatty acid synthesis gene acetyl CoA carboxylase-alpha. alpha-GOSg also significantly reduced the content of bile acids in the small intestine and significantly increased the abundance of gut Bifidobacterium and decreased the abundance of Clostridium leptum. These actions are proposed to be key mechanisms contributing to the beneficial health effects of alpha-GOSg.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据