期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 65, 期 5, 页码 1012-1018出版社
WILEY
DOI: 10.1111/jgs.14732
关键词
midlife; cardiovascular; physical performance
资金
- National Heart, Lung and Blood Institute [HHSN268201100005C, HHSN2682011 00006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN 268201100011C, HHSN268201100012C]
- American Federation for Aging Research
- National Institute on Aging Medical Student Training in Aging Research program
ObjectivesTo examine the association between midlife cardiovascular health and physical performance 25years later. DesignCohort study (Atherosclerosis Risk in Communities Study); multinomial logistic and logistic regression adjusted for demographic characteristics and clinical measures. SettingFour U.S. communities: Forsyth County, North Carolina; Washington County, Maryland; Minneapolis, Minnesota; and Jackson, Mississippi. Participants: Individuals aged 54.25.8 at baseline (N=15,744; 55% female, 27% black). MeasurementsCardiovascular health was measured at baseline using the American Heart Association's Life's Simple 7 (LS7) score (0-14) and LS7 component categories (poor, intermediate, ideal) for each risk factor. The Short Physical Performance Battery (SPPB) was used to quantify physical function as ordinal (0-12) and categorical (low (0-6), fair (7-9), good (10-12) outcomes. ResultsMean baseline LS7 score was 7.9 +/- 2.4; 6,144 (39%) individuals returned 25years later for the fifth ARIC examination, at which point the SPPB was administered. Of 5,916 individuals who completed the SPPB, 3,288 (50%) had good physical performance. Each 1-unit increase in LS7 score was associated with a 17% higher SPPB score (rate ratio (RR)=1.17, 95% confidence interval (CI)=1.15-1.19) and a 29% greater chance of having a late-life SPPB score of 10 or greater compared to SPPB score of less than 10 (RR=1.29, 95% CI=1.25-1.34). Ideal baseline glucose (RR=2.53, 95% CI=2.24-2.87), smoking (RR=1.97, 95% CI=1.81-2.15), blood pressure (RR=1.70, 95% CI=1.54-1.88), body mass index (RR=1.51, 95% CI=1.37-1.66), and physical activity (RR=1.31, 95% CI=1.20-1.43) had the strongest associations with late-life SPPB score, adjusting for other LS7 components. ConclusionBetter cardiovascular health during midlife may lead better physical functioning in older age.
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