期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 69, 期 15, 页码 1952-1967出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2017.01.064
关键词
arterial stiffness; endothelium; epigenetics; stem cells
资金
- Swiss National Science Foundation
- Alfred and Annemarie von Sick Grants for Translational and Clinical Research Cardiology and Oncology
- Pfizer, Inc.
- Foundation for Cardiovascular Research-Zurich Heart House
- U.S. National Institutes of Health [RO1 HL080472]
- RRM Charitable Fund
- Sheikh Khalifa's Foundation at the Faculty of Medicine, University of Zurich
- Amgen
- AstraZeneca
- Esperion Therapeutics
- Ionis Pharmaceuticals
- Kowa Pharmaceuticals
- Merck Co.
- Novartis
- Pfizer
- Sanofi-Regeneron
- Takeda Pharmaceuticals
- XBiotech
Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers, and health systems. Structural and functional alterations of vessels accumulate throughout life, culminating in increased risk of developing CVD. The growing elderly population worldwide highlights the need to understand how aging promotes CVD in order to develop new strategies to confront this challenge. This review provides examples of some major unresolved clinical problems encountered in daily cardiovascular practice as we care for elderly patients. Next, the authors summarize the current understanding of the mechanisms implicated in cardiovascular aging, and the potential for targeting novel pathways implicated in endothelial dysfunction, mitochondrial oxidative stress, chromatin remodeling, and genomic instability. Lastly, the authors consider critical aspects of vascular repair, including autologous transplantation of bone marrow-derived stem cells in elderly patients. (J Am Coll Cardiol 2017; 69: 1952-67) (C) 2017 by the American College of Cardiology Foundation.
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