期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 69, 期 24, 页码 2952-2966出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2017.04.041
关键词
Chinese herbal drugs; dyslipidemia; heart failure; hypertension; randomized controlled trials as topic; type 2 diabetes mellitus
资金
- National 973 Basic Research Program of China [2013CB530703, 2015CB553604]
- National Natural Science Foundation of China [81400284, 81425004, 91339109, 81270350]
- Program of Introducing Talents of Discipline to Universities [B07035]
- State Key Program of National Natural Science of China [61331001, 81530014]
- International Collaboration and Exchange Program of China [81320108004]
- Natural Science Foundation of Shandong Province [ZR2014HM044, ZR2014HP045]
- Clinical Medicine Science and Technology Innovation Plan of Jinan Science and Technology Bureau [201602157, 201506002]
- Shenzhen Science and Technology Research and Development Fund [JCYJ20160331183804137]
Traditional Chinese medicine (TCM) has more than 2,000 years of history and has gained widespread clinical applications. However, the explicit role of TCM in preventing and treating cardiovascular disease remains unclear due to a lack of sound scientific evidence. Currently available randomized controlled trials on TCM are flawed, with small sample sizes and diverse outcomes, making it difficult to draw definite conclusions about the actual benefits and harms of TCM. Here, we systematically assessed the efficacy and safety of TCM for cardiovascular disease, as well as the pharmacological effects of active TCM ingredients on the cardiovascular system and potential mechanisms. Results indicate that TCM might be used as a complementary and alternative approach to the primary and secondary prevention of cardiovascular disease. However, further rigorously designed randomized controlled trials are warranted to assess the effect of TCM on long-term hard endpoints in patients with cardiovascular disease. (C) 2017 by the American College of Cardiology Foundation.
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