期刊
BIOMATERIALS SCIENCE
卷 7, 期 8, 页码 3138-3142出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9bm00785g
关键词
-
资金
- NIH [CA224605]
While highly promising in medicine, gene therapy requires delivery agents to protect and target nucleic acid therapeutics. We developed a plant viral siRNA delivery platform making use of self-assembling cowpea chlorotic mottle virus (CCMV). CCMV was loaded with siRNAs targeting GFP or FOXA1; to further enhance cell uptake and intracellular trafficking, resulting in more efficient gene knockdown, we appended CCMV with a cell penetrating peptide (CPP), specifically M-lycotoxin peptide L17E.
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