期刊
FOOD & FUNCTION
卷 10, 期 7, 页码 4350-4360出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9fo00302a
关键词
-
资金
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the High Value-added Food Technology Development Program - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [116012-3]
- National Research Foundation (NRF) of Korea - Ministry of Science ICT [2017R1E1A1A01074320]
- National Research Foundation of Korea [2017R1E1A1A01074320] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Cinnamon is known to have several physiological effects; the effects of Cinnamomum japonicum Sieb. on anti-inflammation and tight junctions were investigated in the cellular intestinal inflammation model. Cinnamon subcritical water extract (CSWE) significantly down-regulated the protein and expression levels of nitrite, prostaglandin E2 (PGE(2)), interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, nuclear factor kappa B (NF-kappa B) activity, and the phosphorylation of the factors of the NF-kappa B pathway. It also significantly decreased the permeability but increased the transepithelial electrical resistance (TEER) value and the protein and expression levels of tight junction proteins (i.e., zonula occludens (ZO)-1, occludin, and claudin-1). Furthermore, cinnamic acid and cinnamaldehyde, the major components of C. japonicum, inhibited the phosphorylation of the NF-kappa B pathway and increased the tight junction protein expression. CSWE from C. japonicum may improve intestinal health by enhancing tight junctions and inhibiting inflammation of the intestines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据