期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 60, 页码 8716-8721出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc02831e
关键词
-
资金
- National Science Foundation of China [21822103, 21820102003, 21772052, 21772053, 21572074, 21472057]
- Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]
- Natural Science Foundation of Hubei Province [2017AHB047]
- International Joint Research Center for Intelligent Biosensing Technology and Health
The Wittig reaction is a reliable method for synthesizing alkenes from phosphorous ylides (P-ylides) and carbonyls, and is thus widely applied in medicine and pharmaceutical production. Among them, asymmetric Wittig reactions using chiral P-ylides are believed to be a conventional pathway towards chiral alkenes. Obviously, the key of this transformation is the efficient construction of chiral P-ylides. Over the past decade, the coupling of the in situ generated chiral P-ylides through the catalytic asymmetric alkylation of easily available P-ylides and the subsequent Wittig reaction with carbonyls has already been achieved, allowing the efficient and selective synthesis of versatile chiral alkenes. This review highlights these impressive advances according to the catalysis type, and the general mechanisms and stereochemical inductions are briefly discussed as well. We hope this article will be a useful reference and inspiration for those who are exploring new methods and new applications of chiral P-ylides.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据