期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 15, 页码 5313-5316出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b02389
关键词
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资金
- NIH [R01 GM111820, NIH P20 GM104316, P20 GM103541, S10 OD016267]
- University of Delaware (UD)
- Plastino Alumni Undergraduate Research Fellowship program
- NSF [NSF CHE0421224, CHE1229234, CHE0840401, CHE-1048367]
We developed a strategy to harness alkyl amines as alkylating agents via C-N bond activation. This Suzuki Miyaura cross coupling of alkylpyridinium salts, readily formed from primary amines, is the first example of a metal-catalyzed cross coupling via C-N bond activation of an amine with an unactivated alkyl group. This reaction enjoys broad scope and functional group tolerance. Primary and secondary alkyl groups can be installed. Preliminary studies suggest a Ni-I/Ni-II catalytic cycle.
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