期刊
PHYSICAL REVIEW E
卷 100, 期 2, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.100.022401
关键词
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资金
- Deutsche Forschungsgemeinschaft [Sonderforschungsbereich (SFB) 1027]
A living cell senses its environment and responds to external signals. In this paper, we study theoretically the precision at which cells can determine the position of a spatially localized transient extracellular signal. To this end, we focus on the case where the stimulus is converted into the release of a small molecule that acts as a second messenger, for example, Ca2+, and activates kinases that change the activity of enzymes by phosphorylating them. We analyze the spatial distribution of phosphorylation events using stochastic simulations as well as a mean-field approach. Kinases that need to bind to the cell membrane for getting activated provide more accurate estimates than cytosolic kinases. Our results could explain why the rate of Ca2+ detachment from the membrane-binding conventional protein kinase C alpha is larger than its phosphorylation rate.
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