期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 47, 页码 17011-17014出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b10149
关键词
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资金
- National Natural Science Foundation of China [21502124]
- 973 Project from the MOST of China [2015CB856600]
- 1000-Youth Talents Program
- Fundamental Research Funds for the Central Universities
Herein, we report a highly regio- and enantioselective copper-catalyzed reductive hydroxymethylation of styrenes and 1,3-dienes with 1 atm of CO2. Diverse important chiral homobenzylic alcohols were readily prepared from styrenes. Moreover, a variety of 1,3-dienes also were converted to chiral homoallylic alcohols with high yields and excellent regio-, enantio-, and Z/E-selectivities. The utility of this transformation was demonstrated by a broad range of styrenes and 1,3-dienes, facile product modification, and synthesis of bioactive compounds (R)-(-)-curcumene and (S)-(+)-ibuprofen. Mechanistic studies demonstrated the carboxylation of phenylethylcopper complexes with CO2 as one key step.
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