期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 49, 页码 17979-17986出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b09281
关键词
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资金
- German Research Foundation [WE 5922/1]
- NanoNed
- Netherlands Organization for Scientific Research (NWO-CW)
- Netherlands Organization for Scientific Research (NWO VIDI) [723.014.001]
- Royal Netherlands Academy of Arts and Sciences (KNAW)
- Ministry of Education, Culture and Science [024.001.035]
- European Research Council [694345]
The field of photopharmacology aims to introduce smart drugs that, through the incorporation of molecular photoswitches, allow for the remote spatial and temporal control of bioactivity by light. This concept could be particularly beneficial in the treatment of bacterial infections, by reducing the systemic and environmental side effects of antibiotics. A major concern in the realization of such light-responsive drugs is the wavelength of the light that is applied. Studies on the photocontrol of biologically active agents mostly rely on UV light, which is cytotoxic and poorly suited for tissue penetration. In our efforts to develop photoswitchable antibiotics, we introduce here antibacterial agents whose activity can be controlled by visible light, while getting into the therapeutic window. For that purpose, a UV-light-responsive core structure based on diaminopyrimidines with suitable antibacterial properties was identified. Subsequent modification of an azobenzene photoswitch moiety led to structures that allowed us to control their activity against Escherichia coli in both directions with light in the visible region. For the first time, full in situ photocontrol of antibacterial activity in the presence of bacteria was attained with green and violet light. Most remarkably, one of the diaminopyrimidines revealed an at least 8-fold difference in activity before and after irradiation with red light at 652 nm, showcasing the effective activation of a biological agent otherwise inactive within the investigated concentration range, and doing so with red light in the therapeutic window.
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